Atosiban

pDESCRIPTION: Atosiban also called ADH (Anti-Diuretic Hormone) has a molecular formula of C43H67N11O12S2 Mpr-Tyr(OEt)-Ile-Thr-Asn-Cys- Pro- Orn-,Gly-NH2 having a Mw of 994.2 is the first oxytocin antagonist to be specifically developed for the treatment of preterm labour. Atosiban has a specific mode of action, inhibiting oxytocin-induced uterine contractions lry blocking oxytocin receptors in the uterus. Extensive clinical investigations have shown Atosiban to be at least as effective as current tocolytic agents. In addition, due to its novel and specific mode of action, Atosiban has a markedly improved maternal side effects profile compared with conventional therapies.br /
SOURCE: Synthetic peptidebr /
PURITY: gt; 98%, as determined by:br /
(a) Analysis by RP-HPLC and Anion-exchange FPLC.br /
(b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.br /
ENDOTOXIN: lt; 0.1 ng/mu;g (IEU/mu;g) of Atosibanbr /
DIMERS amp; AGGREGATES: lt; 1% as determined by silver stained SDS-PAGE gel analysisbr /
PROTEIN CONTENT: Protein quantitation was carried out by 2 independent methods:br /
- UV spectroscopy at 280 nmbr /
- Analysis by RP-HPLC, using a standard solution of Atosiban as a Reference Standardbr /
FORM: Purified, in 0.1 % BSAbr /
STORAGE: -20deg;C (aliquot), avoid freezing and thawing cycles/p