AKR1C3 (1-323aa, His-tagged), Human

pDESCRIPTION: AKR1C3, also known as PGFS, is a member of the aldo-keto reductase superfamily which catalyzes the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9 alpha, 11 beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and differentiation.br /
Full name: Aldo-keto reductase family 1, member C3br /
Synonyms: DD3, DDX, HA1753, HAKRB, HAKRe, hluPGFS, HSD17B5, KIAA0119br /
AA Sequence:br /
MGSSHHHHHH SSGLVPRGSH MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKLbr /
AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALEbr /
NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLAbr /
KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALGbr /
SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQNbr /
VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEYbr /
SOURCE: Recombinant, His-tagged (N), E.coli expression systembr /
MOLECULAR WEIGHT: 39 kDa (323 aa)br /
PURITY: gt; 95% by SDS PAGEbr /
FORM: Purified, in 20mM Tris-HCl buffer (pH8.0), 10% glycerolbr /
ENDOTOXIN: lt; 1.0 EU per 1 mu;g of protein (determined by LAL method)br /
CONCENTRATION: 1 mg/ml (Bradford Assay)br /
STORAGE: -20deg;C (aliquot), Avoid repeated freeze and thaw cycles/p