AGR 2, human

pDESCRIPTION: AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secretedbr /
Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secretedbr /
molecule of yet weakly defined functions that is widely expressed in human tissues.br /
Expression of AGR2 shows a positive correlation with expression of estrogenbr /
receptor in breast carcinoma and a negative correlation with expression of EGFbr /
receptor.br /
Synonyms: AG2, GOB-4, HAG-2, XAG-2br /
AA Sequence:br /
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASK LLRAVILGPPbr /
GSGKGTVSQR IAQNFGLQHL SSGHFLRENI KASTEVGEMA KQYIEKSLLV PDHVITRLMMbr /
SELENRRGQH WLLDGFPRTL GQAEALDKIC EVDLVISLNI PFETLKDRLS RRWIHPPSGRbr /
VYNLDFNPPH VHGIDDVTGE PLVQQEDDKP EAVAARLRQY KDVAKPVIEL YKSRGVLHQFbr /
SGTETNKIWP YVYTLFSNKI TPIQSKEAYbr /
SOURCE: Recombinant, His-tagged, E. coli expression systembr /
MOLECULAR WEIGHT: 22 kDa (192 aa)br /
PURITY: gt; 95% by SDS PAGEbr /
FORM: Purified, in Phosphate-Buffered Saline (pH 7.4)br /
CONCENTRATION: 1 mg/mlbr /
STORAGE: -20deg;C (aliquot), Avoid repeated freeze and thaw cyclesbr /
REFERENCE:br /
RC F.R.Fritzsche.et al., (2007). Histol Histopathol. 22: 703-708br /
Fletcher GC, Patel S, Tyson K. et al., (2003) Br J Cancer 24;88 (4): 579-585br /
Liu D, Rudland PS, Sibson DR, et al., (2005) Cancer Res. 65: 3796ndash;3805br /
40br /
28br /
18br /
(kDa)br /
15% SDS PAGE/p