Melanoma Marker Antibody (HMB45)

Mouse monoclonal antibody suitable for immunohistochemistry.



Functional Aspects:

This antibody recognizes the majority of melanomas and other tumors that show melanoma/melanocytic differentiation including melanocytic Schwannoma clear cell sarcoma. It does not recognize normal adult melanocytes or non-melanocytic cells. Some staining has been reported in prenatal retinal pigment epithelium and junctional and blue nevus cells and variably with fetal/neonatal melanocytes. The immunogen used to generate the antibody was an extract of pigmented melanoma metastases from lymph nodes.