Sino Biological | AI驅動親和力成熟服務

2022.12.07 最新消息

 

CRO Services Antibody Development & Production Services Protein Expression Services Sino Biological和Ainnocence攜手建立了人工智能(AI)驅動的抗體親和力成熟平台。SentinusAI™是Ainnocence研發的可自我優化的人工智能，可根據對一個或多個抗原的親和力在幾天內預測並高效完成1010個抗體序列的篩选和親和力排序，這種方式也將從技術上徹底改變親和力成熟抗體的篩選過程。結合Sino Biological的高通量重組抗體表達生產平台，親和力較高的抗體序列將交付Sino Biological來快速完成抗體的表達生產以及親和力驗證。經篩选和驗證，高親和力抗體的命中率可達15%，且花費更少，抗體交付時間更短 服務時間 命中率 高親和力 更多資訊 4週 15% 可提升至103倍 服務特點 高達1010的突變序列庫 可獲得抗體序列 無動物實驗 可與人源化服務結合 結合web-lab數據，透過數據的計算，可實驗高精準度 經濟實惠 服務內容 Project Type De novo Ab design Ab Affinity maturation (fixed template) Customer Input • Ag sequences (required) • Any positive or negative Ab sequences (preferred) • Ag sequence (required) • Ab template sequence (required) • Any positive or negative Ab sequences (preferred) • Binding affinity data (preferred) Description • The entire antigen will be assessed for possible epitopes • Existing data from clients might be needed to build a customized AI model. • If an Ab template is to be preserved across all mutant candidate Abs, mutagenesis will only be performed on the CDR regions of VH and VL. • The binding epitope remains the same across all candidate Abs. Deliverable 20-100 ranked antibody sequences  |  Purified Antibodies  |  Project report Timeline 4-6 weeks 其它相關CRO服務 • Antibody Humanization Service • Recombinant Antibody Expression Services • Mammalian Transient Protein Expression Service