Z-Leu-Leu-Leu-CHO (MG-132)
- 貨號 Cat. No.
- I-130
- 規格 Size
- 1 mg 5mg
- 品牌 Brand
- Boston Biochem
Description
Z-Leu-Leu-Leu-CHO (MG-132)
Synthetic
Product Information
1 mg 5mg
> 95% by HPLC.
Soluble in DMSO up to 15 mg/ml. Note: Pellet may have oily appearance.
Ki = 4.2 nM vs. SDS-activated 20S proteasome. IC50 in cell culture = 5 μM.
Use & Storage
Add from DMSO stock directly to in vitro or in vivo assays at desired
concentration. Pre-incubation with compound prior to assay is recommended
for maximal effect.
Store at -20°C. Avoid multiple freeze/thaw cycles.
Catalog #: I-130
Z-Leu-Leu-Leu-CHO (MG-132)
Product Source:
Synthetic
Peptide aldehydes form a covalent hemiacetal adduct with the 20S proteasome, inhibiting the chymotrypsin-like peptidase activity. These inhibitors are reversible and cell-permeable, and also inhibit the activity of calpains and cathepsins.
Product Information
Quantity:
1 mg 5mg
Structure:
Purity:
> 95% by HPLC.
Solubility:
Soluble in DMSO up to 15 mg/ml. Note: Pellet may have oily appearance.
Activity:
Ki = 4.2 nM vs. SDS-activated 20S proteasome. IC50 in cell culture = 5 μM.
Use & Storage
Use:
Add from DMSO stock directly to in vitro or in vivo assays at desired
concentration. Pre-incubation with compound prior to assay is recommended
for maximal effect.
Storage:
Store at -20°C. Avoid multiple freeze/thaw cycles.