Antibodies
Z-IETD-FMK
- 貨號 Cat. No.
- S7314
- 規格 Size
- 5~200mg
- 品牌 Brand
- Selleckchem
Description
Z-IETD-FMK
Catalog No.S7314
Z-IETD-FMK is a specific Caspase-8 inhibitor.
| Availability |
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Biological Activity
| Description | Z-IETD-FMK is a specific Caspase-8 inhibitor. | |||||
|---|---|---|---|---|---|---|
| Targets | Caspase 8 | |||||
| IC50 | [1] | |||||
| In vitro | Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3.[2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. [3] | |||||
| In vivo | In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. [3] Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. [4] | |||||
| Features | ||||||
Protocol(Only for Reference)
Animal Study: [3]
| Animal Models | T. cruzi-infected mice |
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| Dosages | 0.4 mg/3 days |
| Administration |
References
Chemical Information
| Molecular Weight (MW) | 654.68 |
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| Formula | C30H43FN4O11 |
| CAS No. | 210344-98-2 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | Caspase-8 Inhibitor |
| Solubility (25°C) * | In vitro | DMSO | mg/mL (<1 mM) |
|---|---|---|---|
| Water | mg/mL (<1 mM) | ||
| Ethanol | mg/mL (<1 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | L-​Threoninamide, N-​[(phenylmethoxy)​carbonyl]​-​L-​isoleucyl-​L-​α-​glutamyl-​N-​[(1S)​-​3-​fluoro-​1-​(2-​methoxy-​2-​oxoethyl)​-​2-​oxopropyl]​-​, methyl ester |
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