Z-DEVD-FMK(CASPASE3/CPP32 INHIBITOR W-3) Antibody

Caspases play significant roles in both inflammation and apoptosis. Caspases exhibit catalytic and substrate recognition motifs that have been highly conserved. These characteristic amino acid sequences allow caspases to interact with both positive and negative regulators of their activity. The substrate preferences or specificities of individual caspases have been exploited for the development of peptides that successfully compete for caspase binding. DEVD-FMK is a potent inhibitor of caspase-3.