YM155

YM155 (Sepantronium bromide) is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. YM155 also completely inhibited the growth of orthotopically xenografted PC-3 tumors. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM. YM155 is highly distributed to tumors and at concentrations approximately 20-fold higher than those in plasma. YM155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.