XLF Antibody
- 貨號 Cat. No.
- 3757-100
- 規格 Size
- 100 µl
Description
Antibody Target: XLF
Alternative Name: XRCC4-like Factor, Cernunnos, FLJ12610
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Antibody Form: Affinity Purified Antibody
Immunogen: Synthetic peptide of human XLF
Accession#: NP_079058.1
Gene ID: 79840
Appearance: Colorless liquid
Concentration: N/A
Formulation: 100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Purification: Affinity purified
Species Reactivity: human
Application: Western blot, Immunoprecipitation
Application & Usage: Western blotting (1:500 – 1:2500) and Immunoprecipitation. However, the optimal concentrations should be determined individually. The antibody recognizes the XLF of human origin. Reactivity to other species has not been tested.
Storage Temp.: -20 °C
Shipping: gel pack
Shelf Life: 12 months
Background Descriptions: XLF (also called Cernunnos) interacts with the XRCC4-DNA ligase IV complex to promote DNA non-homologous end-joining. It directly interacts with the XRCC4-Ligase IV complex and siRNA-mediated downregulation of XLF in human cell lines leads to radio-sensitivity and impaired DNA non-homologous end-joining. XLF is homologous to the yeast non-homologous end-joining factor Nej1.
Handling: The antibody solution should be gently mixed before use.