XAV939

Alternate Name/Synonyms: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one

Appearance: White solid

Formulation: N/A

CAS Number: 284028-89-3

Molecular Formula: C₁₄H₁₁F₃N₂OS

Molecular Weight: 312.31

Purity: ≥98% by HPLC

Solubility: DMSO (50 mM)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A Tankyrase (TNKS) inhibitor (ICâ‚…â‚€ = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

Handling: Protect from air and light