X-396
Chemical Compounds
- 貨號 Cat. No.
- M1743
- 規格 Size
- 10mg
- 品牌 Brand
- No Brand
Description
X-396 is a potent and highly specific ALK small molecule tyrosine kinase inhibitors (TKIs). In Ambit kinome screens, cell growth inhibition studies, and surrogate kinase assays,X-396 was more potent inhibitors of ALK but less potent inhibitors of MET compared to PF-02341066. X-396 displayed potent antitumor activity in vivo with favorable pharmacokinetic and toxicity profiles.
