w-Agatoxin TK
- 貨號 Cat. No.
- A-530
- 規格 Size
- 5 μg 5x5 μg
Description
w-Agatoxin TK
P/Q Type Cav Channel Blocker
| Product#: | A-530 |
| Sizes: |
| 5 mg |
| 5 x 5 mg |
| M.W.: | 5273 |
| Sequence: | EDNCI AEDYG KCTWG GTKCC RGRPC RCSMI GTNCE CTPRL IMEGL SFA |
| Purity: | >99% |
| Bioassay: |
By using the patch clamp technique, w-Agatoxin TK was shown to block several types of Cav2.1 derived currents (i.e. P and Q with differential inactivation kinetics) in rat cerebral cortex2 and hippocampal3 neurons. In accordance the toxin blocks synaptic transmission as was shown in the corticostriatal of the rat brain with IC50 of 127nM.4
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| References: |
1. | Teramoto, T. et al. (1993) Biochem. Biophys. Res. Commun. 196, 134. |
2. | Teramoto, T. et al. (1997) Brain Res. 756, 225. |
3. | Teramoto, T. et al. (1995) Neuroreport 6, 1684. |
4. | Barral, J. et al. (2001) Eur. J. Pharmacol. 430, 167. |
5. | Adams, M. E. et al. (1993) Mol. Pharm. 44, 681. |
6. | Heck, S. D. et al. (1994) Science 266, 1065. |
7. | Heck, S. D. et al. (1994) J. Amer. Chem. Soc. 116, 10426. |
8. | Yu, H. et al. (1993) Biochemistry 32, 13123. |
w-Agatoxin TK is a synthetic peptide, originally isolated from Agelenopsis aperta spider venom. w-Agatoxin TK was shown to be a selective and reversible blocker of Cav2.1 (P/Q type) channels.1 Originally the toxin was designated w-Agatoxin IVB.5-8