w-Agatoxin IVA
- 貨號 Cat. No.
- A-500
- 規格 Size
- 5 μg 5x5 μg
Description
w-Agatoxin IVA
P/Q-Type Cav Channel Blocker
| Product#: | A-500 |
| Sizes: |
| 5 mg |
| 5 x 5 mg |
w-Agatoxin IVA is a synthetic peptide, originally isolated from Agelenopsis aperta spider venom, and was shown to be a selective blocker of Cav2.1 (P/Q type) channels.1 However, the sensitivity of block depends on the auxiliary b subunit isoform2 and on the splice variant.3 Therefore the effective concentrations of block vary between systems. In accordance the toxin blocks presynaptic Ca2+ currents and synaptic transmission in a variety of synapses.4,5
| M.W.: | 5202 |
| Sequence: | KKKCI AKDYG RCKWG GTPCC RGRGC ICSIM GTNCE CKPRL IMEGL GLA |
| Purity: | >99% |
| Bioassay: |
| w-Agatoxin IVA is widely used in electrophysiological measurements of cloned and native channels.6,7 It is used to assess the role of Cav2.1 channels in synaptic transmission (see ref. 4). In addition it was used to map the spatial distribution of Cav2.1 channels in mouse cerebellar and hippocampal brain slices.8 |
| References: |
1. | Mintz, I. M. et al. (1992) Nature 355, 827. |
2. | Moreno, H. et al. (1997) P.N.A.S. 94, 14042. |
3. | Bourinet, E. et al. (1999) Nat. Neurosci. 2, 407. |
4. | Meir, A. et al. (1999) Physiol. Rev. 79, 1019. |
5. | Stephens, G.J. et al. (2001) Eur. J. Neurosci. 13, 1902. |
6. | Berrow, N.S. et al. (1997) Eur. J. Neurosci. 9, 739. |
7. | Pearson, H.A. et al. (1995) J. Physiol. 482, 493. |
8. | Nakanishi, S. et al. (1995) J. Neurosci. Res. 41, 532. |