Verruculogen
- 貨號 Cat. No.
- V-500
- 規格 Size
- 0.51 mg 5x0.51mg
Description
Verruculogen
A Mycotoxin Blocker of KCa1.1 (BK) Channels
| Product#: | V-500 |
| Sizes: |
| 0.51 mg |
| 5 x 0.51 mg |
| M.W.: | 511.23 |
| Purity: | >98% |
| Bioassay: |
| Verucculogen was tested for its ability to inhibit KCa1.1 channels expressed in Xenopus oocytes. |
 |
| Time course of KCa1.1 channel current amplitude upon application of several mycotoxins including Verruculogen. Current amplitude was reduced by 100 nM Paxilline (a), Penitrem A (b) and Verruculogen (c). The horizontal bars represent period of toxin perfusion. |
| References: |
1. | Selala, M.I. et al. (1991) J. Nat. Prod. 54, 207. |
2. | Knaus, H.-G. et al. (1994) Biochemistry 33, 5819. |
3. | Akoi, T. and Baraban, S. C. (2000) J. Neurophysiol. 83, 3453. |
Verruculogen is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Pentrium A (#P-650) and Paxilline (#P-450).2 Verruculogen enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Verruculogen had similar effects to Iberiotoxin (#RTI-400) in inhibiting the early Ca2+ dependent K+ current in CA1 pyramidal cells.3