VEGFR2 (P957) Antibody
- 貨號 Cat. No.
- BS5542
- 規格 Size
- 100μg
- 品牌 Brand
- Bioworld
Description
pa href=http://www.bioworlde.com/ACE2-%28K465%29-Antibodyimg src=http://www.bioworlde.com/best/template/product/image/img11.gif alt= //astock/p
pimg src=file:///C:/Users/jimmy/AppData/Local/Temp/moz-screenshot-2.jpg alt= //p
h3 class=list6_t1Host: Rabbit/h3
h3 class=list6_t1Reactivity: Human,Mouse/h3
div class=list6_li
h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
/div
div class=list6_li
h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
/div
div class=list6_li
h3 class=list6_t1Specificity/h3
p class=list6_textVEGFR2 (P957) antibody detects endogenous levels of VEGFR2 protein./p
/div
div class=list6_li
h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
/div
div id=pic
div id=IHCpic
div class=imagecontainer
h3Immunohistochemistry (IHC)/h3
img width=240 height=180 alt= src=http://www.bioworlde.com/upload/ihc/5542.jpg id=ipic //div
pImmunohistochemistry (IHC) analyzes of VEGFR2 (P957) antibody in paraffin-embedded human lung carcinoma tissue./p
/div
/div
div class=list6_li
h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
/div
div class=list6_li
h3 class=list6_t1Background/h3
p class=list6_textVEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposirsquo;s sarcoma lesions./p
/div
pimg src=file:///C:/Users/jimmy/AppData/Local/Temp/moz-screenshot-2.jpg alt= //p
h3 class=list6_t1Host: Rabbit/h3
h3 class=list6_t1Reactivity: Human,Mouse/h3
div class=list6_li
h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
/div
div class=list6_li
h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
/div
div class=list6_li
h3 class=list6_t1Specificity/h3
p class=list6_textVEGFR2 (P957) antibody detects endogenous levels of VEGFR2 protein./p
/div
div class=list6_li
h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
/div
div id=pic
div id=IHCpic
div class=imagecontainer
h3Immunohistochemistry (IHC)/h3
img width=240 height=180 alt= src=http://www.bioworlde.com/upload/ihc/5542.jpg id=ipic //div
pImmunohistochemistry (IHC) analyzes of VEGFR2 (P957) antibody in paraffin-embedded human lung carcinoma tissue./p
/div
/div
div class=list6_li
h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
/div
div class=list6_li
h3 class=list6_t1Background/h3
p class=list6_textVEGF receptor 2 is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or serve as binding sites for SH2 and phosphotyrosine binding containing signalling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposirsquo;s sarcoma lesions./p
/div
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