Antibodies
Valproic acid sodium salt (Sodium valproate)
- 貨號 Cat. No.
- S1168
- 規格 Size
- 10mM/1mLã€200mg
- 品牌 Brand
- Selleckchem
Description
Valproic acid sodium salt (Sodium valproate)
Valproic acid sodium salt (Sodium valproate) is a HDAC inhibitor with IC50 of 0.4 mM and also inhibits GABA-transaminase or succinic semialdehyde dehydrogenase.
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Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
Valproic acid sodium salt (Sodium valproate) is a histone deacetylase inhibitor with an IC50 of 0.4 mM and exhibits anticancer, anti-inflammatory and neuroprotective effects. Sodium valproate (VPA) can inhibit the proliferation of tumor cells by inducing G0/G1 phase arrest and cell apoptosis. It displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer’s disease. It also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons. It enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2. [1][2][3]
Chemical Information
Download Valproic acid sodium salt (Sodium valproate) SDF
| Molecular Weight (MW) | 166.19 |
|---|---|
| Formula | C8H15NaO2 |
| CAS No. | 1069-66-5 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in DMSO | |
| Syonnyms | VPA |
| Solubility (25°C) * | In vitro | DMSO | 33 mg/mL (198 mM) |
|---|---|---|---|
| Water | 33 mg/mL (198 mM) | ||
| Ethanol | 33 mg/mL (198 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | sodium 2-propylpentanoate |
|---|
Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
|---|---|---|---|---|
| Mass(mg) | 0.16619 | 1.6619 | 3.3238 | 4.9857 |
Customer Reviews (1)
 Click to enlarge | Rating | |
| Source | Dr. Zhang of Tianjin Medical University. Valproic acid sodium salt (Sodium valproate) purchased from Selleck | |
| Method | Western blot | |
| Cell Lines | ||
| Concentrations | 0-10 μM | |
| Incubation Time | ||
| Results | Increased Histone acetylation in cells treated with Sodium valproate was observed. |
Product Citations (1)
