Antibodies
Valdecoxib
- 貨號 Cat. No.
- S4049
- 規格 Size
- 10mM/1mL~50mg
- 品牌 Brand
- Selleckchem
Description
div class=pro_title01 style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
h1 itemprop=name style=margin: 0px 20px 0px 0px; padding: 0px; font-size: 24px; float: left;Valdecoxib/h1
div class=product_c_title style=margin: 0px 20px 0px 0px; padding: 0px; height: 25px; font-size: 12px; float: left;span class=p_title style=margin: 0px 15px 0px 0px; padding: 0px; float: left;Catalog No.S4049/span/div
p class=new_title style=margin: 5px 0px 10px; padding: 0px; clear: both; font-size: 11px; line-height: 14.399999618530273px;Valdecoxib is a potent and selective inhibitor ofnbsp;b style=margin: 0px; padding: 0px;COX-2/bnbsp;withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 5 nM./p
/div
form id=prodaddfrom action=http://www.selleckchem.com/cart/addCart.jhtml method=post name=sizelist style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
div class=product_record id=selectTotal style=margin: 0px; padding: 0px; background-color: rgb(245, 245, 245); background-position: initial initial; background-repeat: initial initial;
table border=0 cellspacing=0 cellpadding=0 style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 760px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153 style=margin: 0px; padding: 0px 0px 0px 15px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);label style=margin: 0px; padding: 0px;Size/label/th
th width=76 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);Price/th
th width=55 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);Stock/th
th width=74 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);Quantity/th
th width=402 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);nbsp;/th
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 valign=top class=pt style=margin: 0px; padding: 3px 8px;
table width=91% border=0 cellspacing=0 cellpadding=0 style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 373px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;10mM/1mL/labelspan class=in_bg style=margin: 0px 0px 0px 4px; padding: 0px 3px; background-color: rgb(255, 120, 0); color: rgb(255, 255, 255); font-size: 11px; background-position: initial initial; background-repeat: initial initial;In DMSO/span/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 176/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
td width=61 style=margin: 0px; padding: 3px 8px;select name=cartDTOs[1].quantity style=margin: 0px; padding: 0px; border-color: rgb(171, 171, 171); width: 40px;nbsp;
option value=0 style=margin: 0px; padding: 0px;0/option
nbsp;
option value=1 style=margin: 0px; padding: 0px;1/option
nbsp;
option value=2 style=margin: 0px; padding: 0px;2/option
nbsp;
option value=3 style=margin: 0px; padding: 0px;3/option
nbsp;
option value=4 style=margin: 0px; padding: 0px;4/option
nbsp;
option value=5 style=margin: 0px; padding: 0px;5/option
nbsp;
option value=6 style=margin: 0px; padding: 0px;6/option
nbsp;
option value=7 style=margin: 0px; padding: 0px;7/option
nbsp;
option value=8 style=margin: 0px; padding: 0px;8/option
nbsp;
option value=9 style=margin: 0px; padding: 0px;9/option
nbsp;
option value=10 style=margin: 0px; padding: 0px;10/option
nbsp;/select/td
/tr
tr style=margin: 0px; padding: 0px;
td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;10mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 138/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
td width=61 style=margin: 0px; padding: 3px 8px;select name=cartDTOs[0].quantity style=margin: 0px; padding: 0px; border-color: rgb(171, 171, 171); width: 40px;nbsp;
option value=0 style=margin: 0px; padding: 0px;0/option
nbsp;
option value=1 style=margin: 0px; padding: 0px;1/option
nbsp;
option value=2 style=margin: 0px; padding: 0px;2/option
nbsp;
option value=3 style=margin: 0px; padding: 0px;3/option
nbsp;
option value=4 style=margin: 0px; padding: 0px;4/option
nbsp;
option value=5 style=margin: 0px; padding: 0px;5/option
nbsp;
option value=6 style=margin: 0px; padding: 0px;6/option
nbsp;
option value=7 style=margin: 0px; padding: 0px;7/option
nbsp;
option value=8 style=margin: 0px; padding: 0px;8/option
nbsp;
option value=9 style=margin: 0px; padding: 0px;9/option
nbsp;
option value=10 style=margin: 0px; padding: 0px;10/option
nbsp;/select/td
/tr
tr style=margin: 0px; padding: 0px;
td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;50mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 592/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
td width=61 style=margin: 0px; padding: 3px 8px;select name=cartDTOs[2].quantity style=margin: 0px; padding: 0px; border-color: rgb(171, 171, 171); width: 40px;nbsp;
option value=0 style=margin: 0px; padding: 0px;0/option
nbsp;
option value=1 style=margin: 0px; padding: 0px;1/option
nbsp;
option value=2 style=margin: 0px; padding: 0px;2/option
nbsp;
option value=3 style=margin: 0px; padding: 0px;3/option
nbsp;
option value=4 style=margin: 0px; padding: 0px;4/option
nbsp;
option value=5 style=margin: 0px; padding: 0px;5/option
nbsp;
option value=6 style=margin: 0px; padding: 0px;6/option
nbsp;
option value=7 style=margin: 0px; padding: 0px;7/option
nbsp;
option value=8 style=margin: 0px; padding: 0px;8/option
nbsp;
option value=9 style=margin: 0px; padding: 0px;9/option
nbsp;
option value=10 style=margin: 0px; padding: 0px;10/option
nbsp;/select/td
/tr
/tbody
/table
/td
/tr
/tbody
/table
/div
/form
pnbsp;img class=flag_ico src=http://file.selleckchem.com/images/flag/taiwan.png style=font-size: 12px; margin: 0px 3px 0px 0px; padding: 0px; border: none; display: inline-block; width: 20px; height: 20px; vertical-align: middle; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245); alt= /strong style=font-size: 12px; margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245);Distributor/strongspan style=font-size: 12px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245);nbsp;/spanspan class=font11 margin_l style=font-size: 12px; margin: 0px 0px 0px 10px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245);Tel: +886-2-2827-1197span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;a href=mailto:jimmy@new.abscience.com.tw rel=nofollow style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;jimmy@new.abscience.com.tw/a/span/span/p
h3 id=biologicalActivity style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Biological Activity/h3
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Description/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib is a potent and selective inhibitor ofnbsp;b style=margin: 0px; padding: 0px;COX-2/bnbsp;withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 5 nM./td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Targets/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);COX-2/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);IC50/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vitro/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib inhibits LPS-inducedthinsp;PGEspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spannbsp;production in plasma with IC50 of 0.89 mu;M for assessment of the extent of COX-2 inhibition.thinsp; Valdecoxib inhibits TxBspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spannbsp;production in plasma with IC50 of 25.4 mu;M for assessment of the extent of COX-1 inhibition.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spannbsp;Valdecoxib binds to COX-2 with Ka of 1.1times;10span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;5/spannbsp;M/s. The overall saturation binding affinity for COX-2 of Valdecoxib is 2.6 nM. Valdecoxib shows similar activity in the human whole-blood COX assay (COX-2 IC50 = 0.24 mu;M; COX-1 IC50 = 21.9 mu;M).nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/spannbsp;The affinity of [span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;3/spanH]Valdecoxib for COX-2 with Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;D/spannbsp;of 3.2 nM. The binding of Valdecoxib to COX-2 seems to be both rapid and slowly reversible with association rates of 4.5 times; 10span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;6/span/M/min and dissociation rates of 7.0 times; 10span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;-3/span/min (tspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;1/2/spannbsp;of 98 min).nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[3]/a/spannbsp;The percent of dissolved Valdecoxib at 15 min (DPspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;15/span) is 10.5% for Valdecoxib and 50%, 91% and 93% for its hydrophilic derivatives (VALD-beta;Cd, VALD-HPbeta;Cd and VALD-SBE7beta;Cd complexes), respectively.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/span/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vivo/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib administrated orally inhibits rat carrageenan foot pad edema with ED50 of 10.2 mg/kg.thinsp;Valdecoxib administrated orally shows chronic antiinflammatory activity with ED50 of 0.032 mg/kg/day in rat adjuvant arthritis model. Valdecoxib administrated orally shows blockade of prostaglandin production at the inflammatory site with ED50 of 0.02 mg/kg in the rat carrageenan air pouch model.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spannbsp;Valdecoxib demonstrates marked potency in acute and chronic models of inflammation (air pouch ED50 = 0.06 mg/kg; paw edema ED50 = 5.9 mg/kg; adjuvant arthritis ED50 = 0.03 mg/kg) in rats.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/spannbsp;Valdecoxib alone shows slow in vivo absorption giving maximum % inhibition of edema (16%) after a period of 3 hour. In contrast, VALD-beta;Cd and VALD-SBE7beta;Cd complexes shows high absorption rate in vivo achieving more than 50% inhibition of edema in the 1 hour and maximum percentage of inhibition of edema (66%) after a period of 3 hours.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/spannbsp;Valdecoxib (5 mg/kg, po) results in AUC in plasma of 3.58 mu;g*h/mL and 2.08 mu;g*h/mL in males and female mice, respectively. Valdecoxib (5 mg/kg, po) results in AUC red blood cells of 12.1 mu;g*h/mL and 6.42 mu;g*h/mL in males and female mice, respectively.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[5]/a/span/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Features/th
td colspan=6 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib is more potent in inhibiting COX-2 than COX-1./td
/tr
/tbody
/table
h3 id=protocol style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Protocolspan style=margin: 0px; padding: 0px; font-weight: normal;(Only for Reference)/span/h3
h4 style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;Kinase Assay:nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/span/h4
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);COX enzyme assay in vitro/th
td style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 mu;M). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Valdecoxib is preincubated with crude 1% CHAPS homogenates (2-10 mu;g of protein) for 10 min before addition of arachidonic acid. PGE2 formed is detected by ELISA, after a 10 min incubation./td
/tr
/tbody
/table
h4 style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;Animal Study:nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/span/h4
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Animal Models/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Male Sprague-Dawley rats/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formulation/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.5% methyl cellulose and 0.025% Tween-20/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Dosages/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);10.2 mg/kg/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Administration/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Orally/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Solubility/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.5% methylcellulose/0.2% Tween 80, 19 mg/mL/td
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
/tr
/tbody
/table
pa id=s_ref style=margin: 0px; padding: 0px; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; clear: both; float: left; height: 0px; font-size: 0px;1/a/p
h4 class=reference margin_t style=margin: 10px 0px 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;References/h4
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Chemical Information/h3
pa href=http://file.selleckchem.com/downloads/product-sdf/Valdecoxib-s4049.SDF style=margin: -25px 0px 0px 180px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px; float: left;Download Valdecoxib SDF/a/p
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;nbsp;/div
div class=clear style=margin: 0px; padding: 0px; zoom: 1; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab01 fl style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: left;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Molecular Weight (MW)/th
td width=55% style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);314.36/td
/tr
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formula/th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);
p style=margin: 0px; padding: 0px;Cspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;16/spanHspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;14/spanNspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spanOspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;3/spanS/p
/td
/tr
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);CAS No./th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);181695-72-7/td
/tr
/tbody
/table
table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab fr style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: right;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th rowspan=2 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Storage/th
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);3 yearsnbsp;span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-20℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;Powder/span/td
/tr
tr style=margin: 0px; padding: 0px;
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);6 monthsspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-80℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;in DMSO/span/td
/tr
tr style=margin: 0px; padding: 0px;
th width=161 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Syonnyms/th
td width=214 class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);SC-65872, YM-974/td
/tr
/tbody
/table
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden;nbsp;/div
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table mb15 style=margin: 0px 0px 15px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229);
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=12% rowspan=4 style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);strong style=margin: 0px; padding: 0px;Solubility (25deg;C)nbsp;/strongspan class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/span/th
td width=10% rowspan=3 class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vitro/td
td width=50% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);DMSO/td
td width=28% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);63 mg/mL (200 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Water/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);lt;1 mg/mL (lt;1 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Ethanol/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);18 mg/mL (57 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vivo/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.5% methylcellulose/0.2% Tween 80,/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);19 mg/mL/td
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;lt;1 mg/ml means slightly soluble or insoluble.br style=margin: 0px; padding: 0px; /
span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
/tr
/tbody
/table
/div
div style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px; height: 10px;nbsp;/div
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Chemical Name/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-/td
/tr
/tbody
/table
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;nbsp;/div
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Preparing Stock Solutions/h3
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Stock Solution (1ml DMSO)/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);1mM/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);10mM/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);20mM/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);30mM/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Mass(mg)/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.31436/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);3.1436/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);6.2872/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);9.4308/td
/tr
/tbody
/table
div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;a href=http://www.selleckchem.com/molaritycalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; background-color: rgb(255, 239, 187); border: 1px solid rgb(237, 218, 159); background-position: initial initial; background-repeat: initial initial;Molarity Calculator/anbsp;a href=http://www.selleckchem.com/dilutioncalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; background-color: rgb(255, 239, 187); border: 1px solid rgb(237, 218, 159); background-position: initial initial; background-repeat: initial initial;Dilution Calculator/anbsp;a href=http://www.selleckchem.com/molecular-weight-calculator.html style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; background-color: rgb(255, 239, 187); border: 1px solid rgb(237, 218, 159); background-position: initial initial; background-repeat: initial initial;Molecular Weight Calculator/a/div
div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;nbsp;/div
pnbsp;/p
pnbsp;/p
pnbsp;/p
pnbsp;/p
h1 itemprop=name style=margin: 0px 20px 0px 0px; padding: 0px; font-size: 24px; float: left;Valdecoxib/h1
div class=product_c_title style=margin: 0px 20px 0px 0px; padding: 0px; height: 25px; font-size: 12px; float: left;span class=p_title style=margin: 0px 15px 0px 0px; padding: 0px; float: left;Catalog No.S4049/span/div
p class=new_title style=margin: 5px 0px 10px; padding: 0px; clear: both; font-size: 11px; line-height: 14.399999618530273px;Valdecoxib is a potent and selective inhibitor ofnbsp;b style=margin: 0px; padding: 0px;COX-2/bnbsp;withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 5 nM./p
/div
form id=prodaddfrom action=http://www.selleckchem.com/cart/addCart.jhtml method=post name=sizelist style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
div class=product_record id=selectTotal style=margin: 0px; padding: 0px; background-color: rgb(245, 245, 245); background-position: initial initial; background-repeat: initial initial;
table border=0 cellspacing=0 cellpadding=0 style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 760px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153 style=margin: 0px; padding: 0px 0px 0px 15px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);label style=margin: 0px; padding: 0px;Size/label/th
th width=76 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);Price/th
th width=55 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);Stock/th
th width=74 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);Quantity/th
th width=402 style=margin: 0px; padding: 8px; line-height: 14px; font-size: 14px; border-bottom-style: solid; border-bottom-color: rgb(211, 217, 225); background-color: rgb(221, 228, 236);nbsp;/th
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 valign=top class=pt style=margin: 0px; padding: 3px 8px;
table width=91% border=0 cellspacing=0 cellpadding=0 style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 373px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;10mM/1mL/labelspan class=in_bg style=margin: 0px 0px 0px 4px; padding: 0px 3px; background-color: rgb(255, 120, 0); color: rgb(255, 255, 255); font-size: 11px; background-position: initial initial; background-repeat: initial initial;In DMSO/span/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 176/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
td width=61 style=margin: 0px; padding: 3px 8px;select name=cartDTOs[1].quantity style=margin: 0px; padding: 0px; border-color: rgb(171, 171, 171); width: 40px;nbsp;
option value=0 style=margin: 0px; padding: 0px;0/option
nbsp;
option value=1 style=margin: 0px; padding: 0px;1/option
nbsp;
option value=2 style=margin: 0px; padding: 0px;2/option
nbsp;
option value=3 style=margin: 0px; padding: 0px;3/option
nbsp;
option value=4 style=margin: 0px; padding: 0px;4/option
nbsp;
option value=5 style=margin: 0px; padding: 0px;5/option
nbsp;
option value=6 style=margin: 0px; padding: 0px;6/option
nbsp;
option value=7 style=margin: 0px; padding: 0px;7/option
nbsp;
option value=8 style=margin: 0px; padding: 0px;8/option
nbsp;
option value=9 style=margin: 0px; padding: 0px;9/option
nbsp;
option value=10 style=margin: 0px; padding: 0px;10/option
nbsp;/select/td
/tr
tr style=margin: 0px; padding: 0px;
td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;10mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 138/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
td width=61 style=margin: 0px; padding: 3px 8px;select name=cartDTOs[0].quantity style=margin: 0px; padding: 0px; border-color: rgb(171, 171, 171); width: 40px;nbsp;
option value=0 style=margin: 0px; padding: 0px;0/option
nbsp;
option value=1 style=margin: 0px; padding: 0px;1/option
nbsp;
option value=2 style=margin: 0px; padding: 0px;2/option
nbsp;
option value=3 style=margin: 0px; padding: 0px;3/option
nbsp;
option value=4 style=margin: 0px; padding: 0px;4/option
nbsp;
option value=5 style=margin: 0px; padding: 0px;5/option
nbsp;
option value=6 style=margin: 0px; padding: 0px;6/option
nbsp;
option value=7 style=margin: 0px; padding: 0px;7/option
nbsp;
option value=8 style=margin: 0px; padding: 0px;8/option
nbsp;
option value=9 style=margin: 0px; padding: 0px;9/option
nbsp;
option value=10 style=margin: 0px; padding: 0px;10/option
nbsp;/select/td
/tr
tr style=margin: 0px; padding: 0px;
td width=139 style=margin: 0px; padding: 3px 8px;label style=margin: 0px; padding: 0px;50mg/label/td
td width=80 style=margin: 0px; padding: 3px 8px;USD 592/td
td width=62 style=margin: 0px; padding: 3px 8px;In stock/td
td width=61 style=margin: 0px; padding: 3px 8px;select name=cartDTOs[2].quantity style=margin: 0px; padding: 0px; border-color: rgb(171, 171, 171); width: 40px;nbsp;
option value=0 style=margin: 0px; padding: 0px;0/option
nbsp;
option value=1 style=margin: 0px; padding: 0px;1/option
nbsp;
option value=2 style=margin: 0px; padding: 0px;2/option
nbsp;
option value=3 style=margin: 0px; padding: 0px;3/option
nbsp;
option value=4 style=margin: 0px; padding: 0px;4/option
nbsp;
option value=5 style=margin: 0px; padding: 0px;5/option
nbsp;
option value=6 style=margin: 0px; padding: 0px;6/option
nbsp;
option value=7 style=margin: 0px; padding: 0px;7/option
nbsp;
option value=8 style=margin: 0px; padding: 0px;8/option
nbsp;
option value=9 style=margin: 0px; padding: 0px;9/option
nbsp;
option value=10 style=margin: 0px; padding: 0px;10/option
nbsp;/select/td
/tr
/tbody
/table
/td
/tr
/tbody
/table
/div
/form
pnbsp;img class=flag_ico src=http://file.selleckchem.com/images/flag/taiwan.png style=font-size: 12px; margin: 0px 3px 0px 0px; padding: 0px; border: none; display: inline-block; width: 20px; height: 20px; vertical-align: middle; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245); alt= /strong style=font-size: 12px; margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245);Distributor/strongspan style=font-size: 12px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245);nbsp;/spanspan class=font11 margin_l style=font-size: 12px; margin: 0px 0px 0px 10px; padding: 0px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; background-color: rgb(245, 245, 245);Tel: +886-2-2827-1197span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;a href=mailto:jimmy@new.abscience.com.tw rel=nofollow style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;jimmy@new.abscience.com.tw/a/span/span/p
h3 id=biologicalActivity style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Biological Activity/h3
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Description/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib is a potent and selective inhibitor ofnbsp;b style=margin: 0px; padding: 0px;COX-2/bnbsp;withnbsp;b style=margin: 0px; padding: 0px;IC50/bnbsp;of 5 nM./td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Targets/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);COX-2/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);IC50/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);nbsp;/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vitro/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib inhibits LPS-inducedthinsp;PGEspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spannbsp;production in plasma with IC50 of 0.89 mu;M for assessment of the extent of COX-2 inhibition.thinsp; Valdecoxib inhibits TxBspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spannbsp;production in plasma with IC50 of 25.4 mu;M for assessment of the extent of COX-1 inhibition.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spannbsp;Valdecoxib binds to COX-2 with Ka of 1.1times;10span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;5/spannbsp;M/s. The overall saturation binding affinity for COX-2 of Valdecoxib is 2.6 nM. Valdecoxib shows similar activity in the human whole-blood COX assay (COX-2 IC50 = 0.24 mu;M; COX-1 IC50 = 21.9 mu;M).nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/spannbsp;The affinity of [span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;3/spanH]Valdecoxib for COX-2 with Kspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;D/spannbsp;of 3.2 nM. The binding of Valdecoxib to COX-2 seems to be both rapid and slowly reversible with association rates of 4.5 times; 10span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;6/span/M/min and dissociation rates of 7.0 times; 10span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;-3/span/min (tspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;1/2/spannbsp;of 98 min).nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[3]/a/spannbsp;The percent of dissolved Valdecoxib at 15 min (DPspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;15/span) is 10.5% for Valdecoxib and 50%, 91% and 93% for its hydrophilic derivatives (VALD-beta;Cd, VALD-HPbeta;Cd and VALD-SBE7beta;Cd complexes), respectively.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/span/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);i style=margin: 0px; padding: 0px;In vivo/i/th
td colspan=6 style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib administrated orally inhibits rat carrageenan foot pad edema with ED50 of 10.2 mg/kg.thinsp;Valdecoxib administrated orally shows chronic antiinflammatory activity with ED50 of 0.032 mg/kg/day in rat adjuvant arthritis model. Valdecoxib administrated orally shows blockade of prostaglandin production at the inflammatory site with ED50 of 0.02 mg/kg in the rat carrageenan air pouch model.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/spannbsp;Valdecoxib demonstrates marked potency in acute and chronic models of inflammation (air pouch ED50 = 0.06 mg/kg; paw edema ED50 = 5.9 mg/kg; adjuvant arthritis ED50 = 0.03 mg/kg) in rats.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[2]/a/spannbsp;Valdecoxib alone shows slow in vivo absorption giving maximum % inhibition of edema (16%) after a period of 3 hour. In contrast, VALD-beta;Cd and VALD-SBE7beta;Cd complexes shows high absorption rate in vivo achieving more than 50% inhibition of edema in the 1 hour and maximum percentage of inhibition of edema (66%) after a period of 3 hours.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[4]/a/spannbsp;Valdecoxib (5 mg/kg, po) results in AUC in plasma of 3.58 mu;g*h/mL and 2.08 mu;g*h/mL in males and female mice, respectively. Valdecoxib (5 mg/kg, po) results in AUC red blood cells of 12.1 mu;g*h/mL and 6.42 mu;g*h/mL in males and female mice, respectively.nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[5]/a/span/td
/tr
tr style=margin: 0px; padding: 0px;
th style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Features/th
td colspan=6 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Valdecoxib is more potent in inhibiting COX-2 than COX-1./td
/tr
/tbody
/table
h3 id=protocol style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Protocolspan style=margin: 0px; padding: 0px; font-weight: normal;(Only for Reference)/span/h3
h4 style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;Kinase Assay:nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/span/h4
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);COX enzyme assay in vitro/th
td style=margin: 0px; padding: 5px 15px; text-align: justify; border-style: solid; border-color: rgb(229, 229, 229);Expression of COX protein in insect cells is determined by assessing PG-synthetic capability in homogenates from cells incubated for 3 days with COX-1 or COX-2 baculovirus. Cells expressing COX-1 or COX-2 are homogenized and incubated with arachidonic acid (10 mu;M). COX activity is determined by monitoring PG production. No COX activity is detected in mock-infected Sf9 cells. Valdecoxib is preincubated with crude 1% CHAPS homogenates (2-10 mu;g of protein) for 10 min before addition of arachidonic acid. PGE2 formed is detected by ELISA, after a 10 min incubation./td
/tr
/tbody
/table
h4 style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;Animal Study:nbsp;span style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: -0.5em;a href=http://www.selleckchem.com/products/valdecoxib.html#s_ref class=sref style=margin: 0px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer;[1]/a/span/h4
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Animal Models/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Male Sprague-Dawley rats/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formulation/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.5% methyl cellulose and 0.025% Tween-20/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Dosages/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);10.2 mg/kg/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Administration/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Orally/td
/tr
tr style=margin: 0px; padding: 0px;
th width=16% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Solubility/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.5% methylcellulose/0.2% Tween 80, 19 mg/mL/td
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
/tr
/tbody
/table
pa id=s_ref style=margin: 0px; padding: 0px; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px; clear: both; float: left; height: 0px; font-size: 0px;1/a/p
h4 class=reference margin_t style=margin: 10px 0px 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;References/h4
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Chemical Information/h3
pa href=http://file.selleckchem.com/downloads/product-sdf/Valdecoxib-s4049.SDF style=margin: -25px 0px 0px 180px; padding: 0px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px; float: left;Download Valdecoxib SDF/a/p
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;nbsp;/div
div class=clear style=margin: 0px; padding: 0px; zoom: 1; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab01 fl style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: left;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Molecular Weight (MW)/th
td width=55% style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);314.36/td
/tr
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Formula/th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);
p style=margin: 0px; padding: 0px;Cspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;16/spanHspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;14/spanNspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;2/spanOspan style=margin: 0px; padding: 0px; position: relative; vertical-align: baseline; top: 0.25em;3/spanS/p
/td
/tr
tr style=margin: 0px; padding: 0px;
th width=45% style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);CAS No./th
td style=margin: 0px; padding: 5px 0px 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);181695-72-7/td
/tr
/tbody
/table
table width=100% border=0 cellspacing=0 cellpadding=0 class=show_tab fr style=margin: 0px 0px 10px; padding: 0px; border-collapse: collapse; border-spacing: 0px; width: 375px; float: right;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th rowspan=2 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Storage/th
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);3 yearsnbsp;span class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-20℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;Powder/span/td
/tr
tr style=margin: 0px; padding: 0px;
td class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);6 monthsspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;-80℃/spanspan class=margin_l style=margin: 0px 0px 0px 10px; padding: 0px;in DMSO/span/td
/tr
tr style=margin: 0px; padding: 0px;
th width=161 valign=top class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Syonnyms/th
td width=214 class=padding5 style=margin: 0px; padding: 5px 0px 5px 10px; border-style: solid; border-color: rgb(229, 229, 229);SC-65872, YM-974/td
/tr
/tbody
/table
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden;nbsp;/div
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table mb15 style=margin: 0px 0px 15px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229);
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=12% rowspan=4 style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);strong style=margin: 0px; padding: 0px;Solubility (25deg;C)nbsp;/strongspan class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/span/th
td width=10% rowspan=3 class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vitro/td
td width=50% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);DMSO/td
td width=28% style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);63 mg/mL (200 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Water/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);lt;1 mg/mL (lt;1 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Ethanol/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);18 mg/mL (57 mM)/td
/tr
tr style=margin: 0px; padding: 0px;
td class=italic style=margin: 0px; padding: 5px 15px; font-style: italic; border-style: solid; border-color: rgb(229, 229, 229);In vivo/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.5% methylcellulose/0.2% Tween 80,/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);19 mg/mL/td
/tr
tr style=margin: 0px; padding: 0px;
td colspan=4 style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;lt;1 mg/ml means slightly soluble or insoluble.br style=margin: 0px; padding: 0px; /
span class=red style=margin: 0px; padding: 0px; color: rgb(255, 0, 0);*/spannbsp;Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations./td
/tr
/tbody
/table
/div
div style=margin: 0px; padding: 0px; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px; height: 10px;nbsp;/div
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Chemical Name/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Benzenesulfonamide, 4-(5-methyl-3-phenyl-4-isoxazolyl)-/td
/tr
/tbody
/table
div class=clear-both style=margin: 0px; padding: 0px; clear: both; height: 0px; overflow: hidden; font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;nbsp;/div
h3 id=chemicalInformation style=margin: 25px 0px 0px; padding: 0px; height: 25px; font-size: 14px; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;Preparing Stock Solutions/h3
table width=100% border=0 cellspacing=0 cellpadding=0 class=product_show_table style=margin: 0px; padding: 0px; border-collapse: collapse; border-spacing: 0px; border-style: solid; border-color: rgb(229, 229, 229); color: rgb(0, 0, 0); font-family: Arial, Tahoma, Helvetica; font-size: 12px; line-height: 19.200000762939453px;
tbody style=margin: 0px; padding: 0px;
tr style=margin: 0px; padding: 0px;
th width=153px style=margin: 0px; padding: 5px 0px 5px 15px; font-weight: normal; border-style: solid; border-color: rgb(229, 229, 229);Stock Solution (1ml DMSO)/th
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);1mM/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);10mM/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);20mM/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);30mM/td
/tr
tr style=margin: 0px; padding: 0px;
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);Mass(mg)/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);0.31436/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);3.1436/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);6.2872/td
td style=margin: 0px; padding: 5px 15px; border-style: solid; border-color: rgb(229, 229, 229);9.4308/td
/tr
/tbody
/table
div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;a href=http://www.selleckchem.com/molaritycalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; background-color: rgb(255, 239, 187); border: 1px solid rgb(237, 218, 159); background-position: initial initial; background-repeat: initial initial;Molarity Calculator/anbsp;a href=http://www.selleckchem.com/dilutioncalculator.jsp style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; background-color: rgb(255, 239, 187); border: 1px solid rgb(237, 218, 159); background-position: initial initial; background-repeat: initial initial;Dilution Calculator/anbsp;a href=http://www.selleckchem.com/molecular-weight-calculator.html style=margin: 0px 5px 0px 0px; padding: 5px 15px; text-decoration: none; color: rgb(52, 84, 140); cursor: pointer; display: inline-block; background-color: rgb(255, 239, 187); border: 1px solid rgb(237, 218, 159); background-position: initial initial; background-repeat: initial initial;Molecular Weight Calculator/a/div
div class=counter style=margin: 10px 0px 0px; padding: 0px; font-size: 14px; font-weight: bold; font-family: Arial, Tahoma, Helvetica; line-height: 19.200000762939453px;nbsp;/div
pnbsp;/p
pnbsp;/p
pnbsp;/p
pnbsp;/p
