Urokinase Inhibitor Screening Kit (Fluorometric)

Alternate Name : uPA Inhibitor Screening Kit (Fluorometric), urokinase-type plasminogen activator Inhibitor Screening Kit (Fluorometric)

Tag Line :

Simple Assay to Screen Urokinase Inhibitors

Storage Conditions: -20°C

Shelf life: 12 months

Summary :

• Detection Method – Fluorescence (Ex/Em = 350/450 nm)
• Application:
- Screening potential inhibitors of Urokinase
- Characterize/study urokinase inhibitors

Detection Method:

Features & Benefits:

• Rapid & simple
• Reliable test for screening potential inhibitors of Urokinase
• Includes Urokinase-specific Inhibitor [GGACK Dihydrochloride]

Description:

Urokinase (Urokinase-type plasminogen activator, uPA, EC 3.4.21.73) is a serine protease, which catalyzes the conversion of the plasminogen to active plasmin, which in turn participates in thrombolysis. Urokinase inhibitors have potential applications in cancer therapy. Biovision’s Urokinase Inhibitor Screening Kit utilizes the ability of Urokinase to cleave a synthetic AMC-based peptide substrate to release AMC, which can be detected by measuring its fluorescence at Ex/Em = 350/450 nm. In the presence of the Urokinase specific inhibitors, the enzyme activity is inhibited or completely abolished. This assay kit is a simple, sensitive, and rapid tool to screen potential Urokinase inhibitors.