uPAR Antibody

Antibody Target: uPAR

Alternative Name: Urokinase plasminogen activator receptor , PLAUR , uPAR , CD87 , MO3 , UPAR , URKR, Urokinase plasminogen activator surface receptor; U-PAR; uPAR; Monocyte activation antigen Mo3; CD_antigen, CD87

Host: Goat

Antibody Type: Polyclonal

Isotype: Goat IgG

Antibody Form: Affinity Purified Antibody

Immunogen: E. coli expressed recombinant human uPAR

Accession#: Q03405

Gene ID: 5329

Appearance: Colorless liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) purified goat polyclonal antibody in 1X phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal..

Purification: Affinity purified

Species Reactivity: human

Application: Western blot, Immunoprecipitation, Neutralization

Application & Usage: Western blotting (0.5-2 µg/ml), immunoprecipitation (5-10 µg/ml), and neutralization (2-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 55 kDa human uPAR. Reactivity to other species has not been tested.

Storage Temp.: -20 °C

Shipping: gel pack

Shelf Life: 12 months

Background Descriptions: uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum β-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.

Handling: The antibody solution should be gently mixed before use.