uPA Antibody

Urokinase-type plasminogen activator (uPA) specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. uPA cleaves an Arg-|-Val bond in plasminogen to form plasmin. uPA is expressed in the prostate gland and prostate cancers. uPA is available under the name Abbokinase (Abbott) and is used in Pulmonary Embolism (PE) to initiate fibrinolysis.