Ubiquitin

Catalog #: U-100Pf

Highly purified ubiquitin free of glycine and buffer salts which can interfere with chemical and in vitro reactions. Ubiquitin is a 76 amino acid, highly conserved nuclear and cytoplasmic eukaryotic protein. It is covalently attached to substrate proteins by enzymes in the Ubiquitin-Proteasome Pathway (UPP). The major role of ubiquitination is to target cellular proteins for the ATP-dependent degradation by the 26S proteasome and proteasome-independent or regulatory events such as protein localization, activity and function. This protein sequence is for protozoan parasite P.falciparum (NP_701482) which causes malaria. Considering its conserved role among eukaryotes, this system is expected to regulate key molecular events driving the parasite life cycle, including parasite discrete apicomplexan mechanisms such as host cell invasion and apicoplast formation.