UBE2S polyclonal
- 貨號 Cat. No.
- AB-266
- 規格 Size
- 100 μg
- 品牌 Brand
- Boston Biochem
Description
UBE2S polyclonal
rabbit polyclonal
Product Information
100 μg
100 μg in PBS
Rabbit
UBE2S (NP_055316.2) C-terminal synthetic peptide conjugated with KLH.
Rabbit IgG
Human. Other species not tested.
Use & Storage
Western blotting, ELISA and IHC. Investigator should empirically determine optimal working dilutions. Other applications have not yet been tested.
Store at -20oC or -80oC. Aliquot to avoid freeze-thaw cycles.
Catalog #: AB-266
UBE2S polyclonal
Product Source:
rabbit polyclonal
UBE2S (E2-24K, E2-EPF) shares 38% identity with S.cerevisiae Ubc4 with a conserved UBC domain characteristic of ubiquitin E2 conjugating enzymes. This E2 enzyme is over-expressed in common human cancers, suggesting an involvement in oncogenesis, and targets von Hippel-Lindau (VHL) for proteosomal degradation in cells, thereby stabilizing hypoxia-inducible factor (HIF)-1α for ubiquitin-mediated destruction. UbE2S levels correlates inversely with pVHL level in most tumor cell lines. Overexpression of UbE2S in vitro and in vivo boosts tumor-cell proliferation, invasion and metastasis through effects on the pVHL-HIF pathway, and may thus be a novel molecular target for therapeutic intervention.
Product Information
Quantity:
100 μg
Stock:
100 μg in PBS
Host:
Rabbit
Immunogen:
UBE2S (NP_055316.2) C-terminal synthetic peptide conjugated with KLH.
Isotype:
Rabbit IgG
Reactivity:
Human. Other species not tested.
Western Blot Data:
Use & Storage
Use:
Western blotting, ELISA and IHC. Investigator should empirically determine optimal working dilutions. Other applications have not yet been tested.
Storage:
Store at -20oC or -80oC. Aliquot to avoid freeze-thaw cycles.