UBE1L (5B10) Antibody

UBE1L (Ubiquitin-activating enzyme E1 homolog UBE1L) a member of the E1 ubiquitin-activating enzyme family. Modification of proteins with ubiquitin is an important cellular mechanism for targeting. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases or E3s. UBE1L is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. UBE1L is expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation.