Tumor Necrosis Factor alpha [TNFα] (IDK® TNFα), ELISA

Tumor necrosis factor-alpha (TNFα) is a cytokine involved in systemic inflammation.
The primary role of TNFα is in the regulation of immune cells. TNFα stimulates the
acute phase reaction, induces apoptotic cell death, cellular proliferation and differentiation,
inhibits tumor genesis and viral replication. Dysregulation of TNFα production
has been implicated in a variety of human diseases like cancer and Alzheimer.
TNFα is secreted by macrophages, monocytes, neutrophils, T-cells as well as natural
killer cells following their stimulation by bacterial lipopolysaccharides. Human TNFα
is a non-glycosylated protein with a molecular weight of 17.5kDa and a length of
157 amino acids. TNFα shows a wide spectrum of biological activities. It causes cytolysis
and/or cytostasis of many tumor cell lines in vitro. Within hours after injection,
TNFα leads to destruction of small blood vessels within malignant tumors. TNFα enhances
phagocytosis and cytotoxicity in neutrophilic granulocytes and modulates
the expression of many other proteins.
Elevated TNFα serum levels are found in patients suffering from Crohn’s disease, ulcerating
colitis or rheumatoid arthritis.