Tubastatin A hydrochloride

Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 values of 15 nM.Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8.In addition, Tubastatin A displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8,where it displayed 54-fold selectivity. This compound displayed dose-dependent protection against HCA induced neuronal cell death starting at 5 μM with near complete protection at 10 μM.