Tubastatin A

Alternate Name/Synonyms: n-Hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol-5(2H)-yl)methyl)benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: N/A

Molecular Formula: C₂₀H₂₁N₃O₂.C₂HF₃O₂

Molecular Weight: 449.42

Purity: ≥98% by HPLC

Solubility: DMSO

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: Cell-permeable, A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (ICâ‚…â‚€ values of 15 nM for HDAC6 vs 16.4 µM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5 µM with near complete protection at 10 µM.

Handling: Protect from air and light