TSLP[Biotinylated]:IL-7R£ & TSLP R Inhibitor Screening ELISA Kit

Thymic stromal lymphopoietin (TSLP) exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin receptor chain and IL-7R£.The formation of the ternary complex, TSLPR:TSLP: IL-7R£,initiates signaling in cells co-expressing TSLPR and IL-7R£.TSLP has been implicated in a variety of allergic diseases (e.g., atopic dermatitis, bronchial asthma, eosinophilic esophagitis). Therefore, inhibition of TSLP interaction with TSLP receptor complex has been considered a promising strategy to blocks thymic stromal lymphopoietin (TSLP) function and prevents the overreactive immune response to allergic,eosinophilic and other types of airway inflammation associated with severe asthma.