TrkC Antibody

h1 class=titleTrkC Antibody/h1
div id=node-1701 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250897/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Data and Images/h4
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pspan class=inline lefta href=http://www.abbiotec.com/image/trkc-staining-rat-brainimg class=image image-medium title=TrkC staining in rat brain: Paraffin-embedded rat brain is stained with TrkC Antibody (Cat. No. 250897) used at a 1:100 dilution. alt=TrkC staining in rat brain: Paraffin-embedded rat brain is stained with TrkC Antibody (Cat. No. 250897) used at a 1:100 dilution. width=300 height=241 src=http://www.abbiotec.com/files/images/250897_brain.medium.jpg //aspan style=width: 298px class=captionstrongTrkC staining in rat brain: /strongParaffin-embedded rat brain is stained with TrkC Antibody (Cat. No. 250897) used at a 1:100 dilution./span/span/p
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h4Description/h4
pThe Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145. Trk C, the third member of the Trk receptor family, encodes a 140-kDa protein, Trk C gp 140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor complex, NGFR p 175 , binds to neurotrophic factor with low affinity but is required for efficient signaling./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pNT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/Q16288Q16288/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TrkC./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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