TrkB Antibody

h1 class=titleTrkB Antibody/h1
div id=node-1699 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250895/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
h4Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe Trk family of nerve growth factor receptors includes Trk A (also reffered to as Trk A gpl140) Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140 kDa cell surface receptor, gp140 , the expression of which is restriced in vivo to neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent , NT-3 , but not NGF can induce tyrosine phosphorylation of Trk B gp 145. The third member of the Trk receptor family , Trk C encodes a 140 kDa protein, Trk C gp 140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor complex, NGFR p 175 , binds to neurtrophic factor with low affinity but is required for efficent signaling. NGFR p175 accelerates Trk activation and may recruit downstream defector moecules to the ligand - bound receptor complex./p
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h4Product Citations/h4
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h4Alternate Names/h4
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h4Accession No./h4
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the N/C-term region of human protein./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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