TrkA Antibody

h1 class=titleTrkA Antibody/h1
div id=node-1697 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250893/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pThe Trk family of nerve growth factor receptors includes TrkA, TrkB and TrkC. The prototype member of this gene family, TrkA encodes a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA exists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pHigh affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P04629P04629/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TrkA./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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