Antibodies
Trifluoperazine 2HCl
- 貨號 Cat. No.
- S3201
- 規格 Size
- 10mM/1mLã€50mg
- 品牌 Brand
- Selleckchem
Description
Trifluoperazine 2HCl
Catalog No.S3201
Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
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Biological Activity
| Description | Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. | |||||
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| Targets | Dopamine D2 | |||||
| IC50 | 1.1 nM [1] | |||||
| In vitro | Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3]Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5] | |||||
| In vivo | Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6] | |||||
| Features | ||||||
Protocol(Only for Reference)
Kinase Assay: [1]
| Binding assay | Receptor binding studies are conducted using membranes from the cloned dopamine D2 receptor. For both receptors the ligand used is [3H]YM-09151-2 (specific activity 86.1 Ci/mmol). Incubation is for 1 hour at room temperature and samples are filtered over glass fiber filters using a cell harvester. The non-specific binding determinant is 1 μM haloperidol. Saturation studies are conducted with [3H]YM-09151-2 in both the dopamine D2 and D4 receptor membranes on several different occasions. Data are analyzed using non-linear analysis programs. Compound affinities are determined using at least six different concentrations in triplicate for dopamine D2 receptor binding studies. IC50 values are converted to Ki values using the standard methods equation and in cases where more than one determination is made, the results are combined using an average weighting method. |
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References
Chemical Information
Download Trifluoperazine 2HCl SDF
| Molecular Weight (MW) | 480.42 |
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| Formula | C21H24F3N3S.2HCl |
| CAS No. | 440-17-5 |
| Storage | 3 years -20℃Powder |
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| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 88 mg/mL (183 mM) |
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| Water | 96 mg/mL (199 mM) | ||
| Ethanol | 96 mg/mL (199 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2) |
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Preparing Stock Solutions
| Stock Solution (1ml DMSO) | 1mM | 10mM | 20mM | 30mM |
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| Mass(mg) | 0.48042 | 4.8042 | 9.6084 | 14.4126 |
