Triciribine phosphate

Triciribine phosphate (NSC-280594) is a novel potent, small-molecule Akt inhibitor. Triciribine phosphate (NSC-280594) prevents the phosphorylation of Akt. Triciribine phosphate (NSC-280594) disrupts a specific signaling pathway associated with chemoresistance and cancer cell survival in ovarian cancer.?Triciribine phosphate (NSC-280594)?in combination with trastuzumab was shown to inhibit cell growth and induce cell death in breast cancer cells that were previously trastuzumab resistant. Triciribine phosphate (NSC-280594) has been demonstrated anti-tumor activity against a wide spectrum of cancers in preclinical and clinical studies. Triciribine phosphate (NSC-280594) is a nucleotide derivative first synthesized by Schram and Townsend.