Trichostatin A

MOLECULAR FORMULA: C₁₇H₂₂N₂O₃ 

MOLECULAR WEIGHT: 302.4

CAS: 58880-19-6

SOURCE: Isolated from Streptomyces hygroscopicus

PURITY: >99%

APPEARANCE: Whitish film adhered to inside of vial

SOLUBILITY: Soluble in DMSO or ethanol

STORAGE CONDITIONS:

Store at -20^oC (before reconstitution). Following reconstitution at DMSO, aliquot and freeze at –20^oC (stable for 6 months). Following reconstitution at ethanol, store at 4^oC (stable for 2-3 months).

DESCRIPTION:

Potent, reversible inhibitor of histone deacetylase. Mediates the activation of O⁶-methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types, induces cell growth arrest at both G1 and G2/M phases. In some cases induces apoptosis.