Antibodies
Tranylcypromine (2-PCPA) HCl
- 貨號 Cat. No.
- S4246
- 規格 Size
- 50mg
- 品牌 Brand
- Selleckchem
Description
Tranylcypromine (2-PCPA) HCl
Catalog No.S4246
Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.
| Size | Price | Stock | Quantity | ||||
|---|---|---|---|---|---|---|---|
| |||||||
Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw
Biological Activity
| Description | Tranylcypromine is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. | |||||
|---|---|---|---|---|---|---|
| Targets | CYP2A6 | |||||
| IC50 | 0.08 μM (Ki) [1] | |||||
| In vitro | R-(+)-Tranylcypromine, (±)-Tranylcypromine, and S-(−)-Tranylcypromine competitively inhibits CYP2A6-mediated metabolism of nicotine with apparent Ki values of 0.05 μM, 0.08 μM, and 2.0 μM, respectively, in human liver microsomes. [1] Tranylcypromine (500 μg/mL) severely inhibits bradykinin-stimulated arachidonic acid release in calf aortic endothelial cells. [2] Tranylcypromine inhibits CYP2A6 and CYP2E1 activity with IC50 of 0.42 μM and 3 μM, respectively, in human liver microsomes. Tranylcypromine induces type II and cyclopropylbenzene type I difference spectrum in human liver microsomes. [3] | |||||
| In vivo | Tranylcypromine injection leads to a large, slow increase in motor activity at 5 mg/kg and 10 mg/kg compared with the saline control in male rats, although 2 mg/kg Tranylcypromine does not induce an increase. Tranylcypromine (10 mg/kg) also causes significant decreases in the number of rearing behaviors in male rats.[4] | |||||
| Features | ||||||
Protocol(Only for Reference)
References
Chemical Information
Download Tranylcypromine (2-PCPA) HCl SDF
| Molecular Weight (MW) | 169.65 |
|---|---|
| Formula | C9H11N.HCl |
| CAS No. | 4548-34-9 |
| Storage | 3 years -20℃Powder |
|---|---|
| 6 months-80℃in DMSO | |
| Syonnyms | N/A |
| Solubility (25°C) * | In vitro | DMSO | 34 mg/mL (200 mM) |
|---|---|---|---|
| Water | 34 mg/mL (200 mM) | ||
| Ethanol | 34 mg/mL (200 mM) | ||
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
| Chemical Name | Cyclopropanamine, 2-phenyl-, hydrochloride (1:1), (1S,2R)- |
|---|
