TLR1 Antibody

Antibody Target: TLR1

Host: Goat

Antibody Type: Polyclonal

Isotype: Goat IgG

Antibody Form: Affinity Purified Antibody

Immunogen: Recombinant human TLR1

Accession#: Q15399

Gene ID: 7096

Appearance: Colorless liquid

Concentration: N/A

Formulation: 100 µl antigen affinity purified goat polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal.

Purification: Affinity purified

Species Reactivity: hu

Application: WB/E

Application & Usage: Western blotting (1:200-1000) and ELISA (1:100-500). However, the optimal concentrations should be determined individually.

Storage Temp.: -20 °C

Shipping : gel pack

Shelf Life: 12 months

Handling: The antibody solution should be gently mixed before use.

Brief Background Descriptions: The TLR (toll-like receptors) family of proteins are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transduction. TLR1, as well as the other TLR family members, are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride (LPS) stimulation, which results in the activation and translocation of NF?B and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes. TLR6 is highly homologous to TLR1, sharing greater that 65% sequence identity, and, like other members of TLR family, it induces NF?B signaling upon activation.