Kits
Thyroglobulin (hTG) recovery ELISA
Kits
Description
Human thyroglobulin (hTG) is a large glycoprotein (MW 660.000 Da) that is stored
in the follicular colloid of the thyroid gland. It functions as a prohormone in the intrathyroid
synthesis of T3 and T4. Traditionally circulating levels of hTG have been
measured using double antibody immunoassays. HTG is evaluated in thyroid follicular
and papillary carcinoma, thyroid adenoma, subacute thyroiditis, Hashimoto´s
thyroiditis and Grave´s disease. HTG levels are not increased in patients with medullary
thyroid carcinoma. Low hTG concentrations are an indication that thyrotoxicosis
factitia may be present. Measurement of hTG is most useful in detecting recurrence
of differentiated thyroid carcinoma following surgical resection or radioactive iodine
ablation. HTG determination is used as an adjunct to iodine 131 scanning but not
as a replacement for it. Assessment of serum hTG also aids in the management of
infants with congenital hypothyroidism.
in the follicular colloid of the thyroid gland. It functions as a prohormone in the intrathyroid
synthesis of T3 and T4. Traditionally circulating levels of hTG have been
measured using double antibody immunoassays. HTG is evaluated in thyroid follicular
and papillary carcinoma, thyroid adenoma, subacute thyroiditis, Hashimoto´s
thyroiditis and Grave´s disease. HTG levels are not increased in patients with medullary
thyroid carcinoma. Low hTG concentrations are an indication that thyrotoxicosis
factitia may be present. Measurement of hTG is most useful in detecting recurrence
of differentiated thyroid carcinoma following surgical resection or radioactive iodine
ablation. HTG determination is used as an adjunct to iodine 131 scanning but not
as a replacement for it. Assessment of serum hTG also aids in the management of
infants with congenital hypothyroidism.