Kits
Thymosin β4, ELISA
- 貨號 Cat. No.
- K 9520
- 規格 Size
- 96 Tests
- 品牌 Brand
- IDS
Description
| Article number: | K 9520 |
| Method: | ELISA |
| Tests: | 96 Tests |
| Matrix: | Serum, Seminal Plasma, Cell Culture Supernatant, Thymus extract |
| Volume: | 50 µl |
| Incubation time: | 1h; 1h; 20min |
| Standards: | 0.16-10 µg/ml |
| The beta-thymosins are a family of highly conserved polar 5 kDa peptides originally thought to be thymic hormones. Further studies demonstrated that the molecule is ubiquitous; it had been found in a variety of tissues and cell lines. It is found in highest concentrations in spleen, thymus, lung, and peritoneal macrophages. Thymosin beta 4 binds monomeric actin in a 1:1 complex and act as actin buffers, preventing polymerization into actin filaments but supplying a pool of actin monomers when the cell needs filaments. Changes in the expression of thymosin beta 4 appear to be related to the differentiation of cells. Thymosin beta 4 is detected outside of cells in blood plasma or in wound fluid. Several biological effects are attributed to thymosin beta 4, like induction of metallo-proteinases, chemotaxis, angiogenesis and inhibition of inflammation as well as the inhibition of bone marrow stem cell proliferation. |