Thioguanine (2C2) Antibody

h1 class=titleThioguanine (2C2) Antibody/h1
div id=node-560 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250360/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
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Format/h4
pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
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h4Description/h4
pThioguanine is a purine analogue used in cancer chemotherapy. It is the 6-thione analogue of the endogenous 6-OH purine base guanine. In the cell thioguanine is converted to the ribonucleotides: 6-thioguanosine-5'-phosphate and 6-thioinosine-5'-phosphate. These fraudulent nucleotides produce their cytotoxic effects by several mechanisms, e.g. inhibitory action on de novo purine synthesis, and may themselves be incorporated into DNA. Thioguanine has a molecular weight of 167 Da. This antibody is specific for thioguanine. Cross-reactivity is seen with 6-(methylthio)purine, but not with various other thioguanine analogs./p
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h4Product Citations/h4
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h4Recommended Products/h4
pa href=http://abbiotec.com/antibodies/thioguanine-%286f7%29-antibody250363 Thioguanine (6F7) Antibody/abr /
a href=http://abbiotec.com/antibodies/thioguanine-%285b2%29-antibody250349 Thioguanine (5B2) Antibody/abr /
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h4Alternate Names/h4
pHGPRT;nbsp; HGPRTase/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/P00492P00492/abr /
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h4Clonality/h4
p2C2/p
h4Antigen/h4
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pS-substituted thioguanine linked to PPD (2)/p
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h4Application Notes/h4
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pProduct Cat. No. 250360 reacts strongly with thioguanine coupled to a carrier protein via the sulfur atom in the 6-position. Antibody binding is inhibited with free thioguanine./p
pE: 1:1,000/p
pstrongReacts with/strongnbsp; :Other/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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