Thalidomide

貨號 Cat. No.: S1193
規格 Size: 5~200mg
品牌 Brand: Selleckchem

Description

Thalidomide

Catalog No.S1193

Thalidomide was introduced as a sedative drug, immunomodulatory agent and also is investigated for treating symptoms of many cancers. Thalidomide inhibits an E3 ubiquitin ligase, which is a CRBN-DDB1-Cul4A complex.Phase 3.

Size

Price

Stock

Quantity

10mM/1mLIn DMSO	USD 239	In stock	0 1 2 3 4 5 6 7 8 9 10
200mg	USD 185	In stock	0 1 2 3 4 5 6 7 8 9 10

Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw

Biological Activity

Thalidomide was introduced as a sedative drug in the late 1950s. However, it was withdrawn due to a teratogenic effect on fetal development. Thalidomide binds to inactivate the protein cereblon, which is important to limb formation. ^[1]

There is now a growing clinical interest in thalidomide since it is introduced as an immunomodulatory agent used primarily, combined with dexamethasone, to treat multiple myeloma. The combination of thalidomide and dexamethasone, often in combination with melphalan, is now one of the most common regimens for patients with newly diagnosed multiple myeloma, with an improved response rate of up to 60-70%. ^[1]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number	Recruitment	Conditions	Sponsor /Collaborators	Start Date	Phases
NCT01927718	Not yet recruiting	Myeloma	M.D. Anderson Cancer Center\|Celgene Corporation	2014-02
NCT01889420	Not yet recruiting	Multiple Myeloma in Relapse	New Mexico Cancer Care Alliance\|Novartis Corporation	2014-02	Phase 1
NCT02018523	Not yet recruiting	Carcinoma, Non-Small-Cell Lung	Baylor College of Medicine\|Jun Zhang\|Celgene Corporation	2014-02	Phase 1
NCT01946152	Not yet recruiting	Myeloma	M.D. Anderson Cancer Center\|Celgene Corporation	2014-02	Phase 1\|Phase 2
NCT01996865	Not yet recruiting	Lymphoma, Non-Hodgkin	Celgene Corporation	2014-02	Phase 3

Chemical Information

Download Thalidomide SDF

Molecular Weight (MW)	258.23
Formula	C₁₃H₁₀N₂O₄
CAS No.	50-35-1

Storage	3 years -20â„ƒPowder
Storage	6 months-80â„ƒin DMSO
Syonnyms	Thalomid

Solubility (25°C) *	In vitro	DMSO	52 mg/mL (201 mM)
		Water	<1 mg/mL (<1 mM)
		Ethanol	2 mg/mL (7 mM)
	In vivo	30% PEG400/0.5% Tween80/5% propylene glycol,	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.