TGF-beta Receptor Type I Antibody

h1 class=titleTGF-beta Receptor Type I Antibody/h1
div id=node-1088 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250879/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
h4Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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pspan class=inline lefta href=http://www.abbiotec.com/image/tgf-beta-receptor-type-i-staining-mouse-liverimg class=image image-medium title=TGF-beta Receptor Type I staining in mouse liver: Mouse cancerous liver tissue is stained with TGF-beta Receptor Type I Antibody (Cat. No. 250879) used at a 1:100 dilution. alt=TGF-beta Receptor Type I staining in mouse liver: Mouse cancerous liver tissue is stained with TGF-beta Receptor Type I Antibody (Cat. No. 250879) used at a 1:100 dilution. width=300 height=225 src=http://www.abbiotec.com/files/images/250879_mouseliver.medium.jpg //aspan style=width: 298px class=captionstrongTGF-beta Receptor Type I staining in mouse liver: /strongMouse cancerous liver tissue is stained with TGF-beta Receptor Type I Antibody (Cat. No. 250879) used at a 1:100 dilution./span/span/p
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h4Description/h4
pTGF-beta receptor type I (TGFR1) forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors that autophosphorylate and activate SMAD transcriptional regulators. Although TGFR1 is ubiquitously expressed, it is found most abundant in placenta and least abundant in brain and heart. Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1 and 2 (aortic aneurysm syndromes)./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pTGF-beta receptor type-1; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TGF-beta type I receptor; TbetaR-I; TGFR-1; Serine/threonine-protein kinase receptor R4; SKR4; Activin receptor-like kinase 5; ALK5; TGFBR1/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P36897P36897/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TGFR1./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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