Tetrodotoxin (with citrate)

Tetrodotoxin (with citrate)

Classic Blocker of Subset Na_v Channels

Product#:

T-550

Sizes:

1 mg

5 x 1 mg

Tetrodotoxin (TTX) is an established potent and selective blocker of some Na_v channels.¹

Moreover, TTX sensitivity is used to define subclasses of Na_v channels.²

It is widely used both to probe Na_v activity and to reduce or block excitability

in neurophysiological preparations.

M.W.:

319.28

Purity:

>98%

Bioassay:

Inhibition of native NaV currents in ND7-23 cells by TTX.

Legend: Top: Time course of native inward current amplitude elicited from holding potential of -100 mV by a 40 ms test pulse to -10 mV delivered every 15 seconds. period of application of 60 nM TTX is marked by different color of symbols (cyan). Bottom: superimposed current traces from the experiment shown on top, before (blue) and during (cyan) bath perfusion of 60 nM TTX.

References:

1.	Narahashi, T. et al. (1964) J. Gen. Physiol. 47, 965.
2.	Hille, B. (2001) In: Ion Channels in Excitable Membranes (third edition) chapter 3.