Tetrodotoxin (citrate free)
- 貨號 Cat. No.
- T-500
- 規格 Size
- 1 mg 5x1mg
Description
Tetrodotoxin (citrate free)
Classic Blocker of Subset Nav Channels
| Product#: | T-500 |
| Sizes: |
| 1 mg |
| 5 x 1 mg |
Tetrodotoxin (TTX) is an established potent and selective blocker of some Nav channels.1
Moreover, TTX sensitivity is used to define subclasses of Nav channels.2
It is widely used both to probe Nav activity and to reduce or block excitability
in neurophysiological preparations.
| M.W.: | 319.28 |
| Purity: | >98% |
| Bioassay: |
| Inhibition of Nav currents in different cell lines by TTX. |
 |
Legend: Potent inhibition of NaV currents by low (60 nM) concentrations of TTX in NGF treated PC-12 (top) and ND7-23 (bottom) cell lines. Left: Time course of inward current amplitude, upon bath application (marked by the horizontal bars) and wash of TTX. Membrane potential was clamped to -120 mV and currents were elicited by 20 ms test pulses to -10 or -20 mV (top and bottom respectively), delivered every 10 seconds. Right: Superimposed traces of control current (before TTX perfusion, red) and during perfusion of 60 nM TTX (black). |
| References: |
1. | Narahashi, T. et al. (1964) J. Gen. Physiol. 47, 965. |
2. | Hille, B. (2001) In: Ion Channels in Excitable Membranes (third edition) chapter 3. |