Terbutaline Sulfate

Description

Description

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

β2-adrenergic receptor

In vitro

Terbutaline is a relatively selective β2-adrenergic bronchodilator that has little or no effect on alpha-adrenergic receptors. The drug has exerts a preferential effect on β2-adrenergic receptors but stimulates beta-adrenergic receptors less selectively than relatively selective beta2-agonists. Terbutaline inhibits antigen-induced histamine release from passively sensitized human lung tissue, which contributes to the clinical effectiveness of the drug during treatment of allergic asthma.[1] Terbutaline also shows competitive reversible inhibition for all BChE variants. The dissociation constants for UU, FF and AA homozygotes are 0.18, 0.31 and 3.3 mM, respectively. [2]

Terbutaline appears to have a greater stimulating effect on beta-receptors of the bronchial, vascular, and uterine smooth muscles (β2 receptors) than on the beta-receptors of the heart (β1 receptors). This drug relaxes smooth muscle and inhibits uterine contractions, but may also cause some cardiostimulatory effects and CNS stimulation. [3]

Terbutaline Sulfate

Catalog No.S4127

Terbutaline Sulfate is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.

Size

Price

Stock

Quantity

50mg

USD 122

In stock

0

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Solubility (25°C) *	In vitro	DMSO	<1 mg/mL (<1 mM)
		Water	100 mg/mL (182 mM)
		Ethanol	<1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.