Tau Protein Antibody

h1 class=titleTau Protein Antibody/h1
div id=node-1348 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250873/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Description/h4
pTau protein promotes microtubule assembly and stability. Tau is also involved in the establishment and maintenance of neural polarity. The C-terminus domain of Tau binds to axonal microtubules whereas the N-terminus domain binds to neural plasma membrane components, therefore suggesting that Tau protein functions as a linker between the two. Axonal polarity is predetermined by tau localization in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. PNS-tau is expressed in the peripheral nervous system whereas the other isoforms are expressed in the central nervous system. Defects in Tau protein are a cause of dementia, parkinsonism and Alzheimer disease./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pMicrotubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1, TAU/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/P10636P10636/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Tau protein./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:100-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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