Survivin, human recombinant

Alternate Names / Synonyms: BIRC5; API4; EPR-1

Gene Symbol: BIRC5

Accession #: O15392

Gene ID: 332

Gene Source: Human

Recombinant Host: E. coli

Appearance: Lyophilized protein

Physical Form: Sterile filtered and lyophilized with no additives

Molecular Weight: 18.6 kDa

Purity by SDS-PAGE: ≥90%

Purity by HPLC: N/A

Endotoxin Level: <0.1 ng/μg

Biological Activity: N/A

Reconstitution: Reconstitute to a concentration of 0.1-1.0 mg/ml in PBS.

Storage Temp.: -20°C

Shipping: Blue ice

Background Information: Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Disruption of survivin induction pathways leads to an increase in apoptosis and decrease in tumour growth. Survivin is highly expressed in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells, making survivin an ideal target for studying cancer therapy.

Handling: Centrifuge the vial prior to opening.