Survivin Antibody

Antibody Target: Survivin/TIAP

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Antibody Form: Affinity Purified Antibody

Immunogen: Synthetic peptide surrounding amino acids near the C-terminus of mouse survivin

Accession#: NP_033819

Gene ID: 11799

Appearance: Colorless liquid

Concentration: 0.2 mg/ml

Formulation: 100 µg (0.2 mg/ml) affinity-purified rabbit anti-Survivin polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% sodium azide.

Purification: Affinity purified

Species Reactivity: ms

Application: WB

Application & Usage: Western blot analysis (0.5 - 2 µg/ml). However, the optimal conditions should be determined individually. The immunoaffinity purified antibody detects an approximately 17 kDa mouse survivin by Western blot analysis. Mouse spleen tissue lysate can be used as positive control.

Storage Temp.: -20 °C

Shipping : gel pack

Shelf Life: 12 months

Handling: The antibody solution should be gently mixed before use.

Brief Background Descriptions: Survivin is a newly described apoptosis inhibitor that is expressed in many human cancers, but undetectable in terminally differentiated adult tissues. It has been shown that recombinant expression of Survivin conteracts apoptosis of B lymphocyte precursors deprived of interleukin 3 (IL-3), suggesting a potential role of Survivin in cancer therapy. Survivin interacts with the processed form of caspase-3 and inhibits its proteolytic activity.