Surfactant protein A (6F10) Antibody

h1 class=titleSurfactant protein A (6F10) Antibody/h1
div id=node-600 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250400/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
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Format/h4
pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
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h4Description/h4
pSurfactant protein A (SP-A) is synthesized and secreted by lung epithelial cells. It belongs to group III of the family of C-type lectins and members of this group has overall structure consisting of multiple globular 'head' regions linked by triple-helical, collagen-like, strands. This group also includes SP-D and the serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shown to bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown to enhance oxygen radical production by alveolar macrophages. The serum concentration is 45 ng/ml in healthy individuals. This antibody is specific for human pulmonary SP-A./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pPulmonary surfactant-associated protein A1;nbsp; SP-A1;nbsp; SP-A; PSP-A;nbsp; PSPA;nbsp; Alveolar proteinosis protein;nbsp; 35 kDa pulmonary surfactant-associated protein/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q8IWL2Q8IWL2/abr /
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h4Clonality/h4
p6F10/p
h4Antigen/h4
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pNative SP-A purified from bronchioaveolar lavage from proteinosis patients/p
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h4Application Notes/h4
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pProduct Cat. No. 250400 reacts in western blot with reduced forms of SP-A, but weakly with non-reduced forms. Product Cat. No. 250400 reacts specifically with human SP-A in immunohistochemical staining of paraffin-embedded tissue samples. Immunoreactivity is seen in alveolar type II cells, nonciliated bronchial cells and a subset of alveolar macrophages. No reactivity is seen in samples from pancreas, intestines, thymus, prostate gland and peritoneal cavity-lining cells. Product Cat. No. 250400 reacts strongly in ELISA with SP-A directly coated onto the microtiter well.nbsp;/p
pE: 1:16,000/p
pWB: 1:1,000/p
pIHC: 1:3,000/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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