Suplatast Tosylate

Suplatast tosylate is a Th2 cytokine inhibitor which is used as an anti-allergic drug. Suplatast tosylate is a novel anti-allergic agent that suppresses several processes, including the synthesis of IL-4 and IL-5 in both human and murine Th2 (-like) cells; IgE synthesis in both mice and humans, with no direct effect on B cells; local eosinophilia regulated by Th2 cells in mice; and infiltration of both eosinophils and CD41 T cells into the airways, with consequent airway hyperresponsiveness after allergen inhalation in sensitized guinea pigs.