Sulbactam sodium

Sulbactam sodium (Unasyn) is an irreversible β-lactamase inhibitor. Sulbactam sodium (Unasyn) binds the enzyme and does not allow it to interact with the antibiotic. Sulbactam sodium (Unasyn) is used as the sodium salt to increase the antibacterial activity of penicillins and cephalosporins against β-lactamase–producing organisms. Sulbactam sodium (Unasyn) confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.